ENT Updates
Clinical Research

Effect of p16 positivity in oral cavity and oropharyngeal squamous cell carcinoma

1.

Department of Otorhinolaryngology, Faculty of Medicine, Izmir Katip Çelebi University, Izmir, Turkey

2.

Department of Otorhinolaryngology, Izmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey

3.

Department of Pathology, Izmir Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey

ENT Updates 2017; 7: 71-21
DOI: 10.2399/jmu.2017001009
Read: 28 Downloads: 26 Published: 26 January 2021

Objective: To determine the frequency of p16 positivity in oral cavity and oropharyngeal squamous cell carcinoma (OC/OP-SCC) and to reveal whether there is a difference between p16-positive and -negative cases according to clinicopathological parameters.
Methods: p16 antibody was retrospectively analyzed immunohistochemically in biopsies of 60 patients with OC/OP-SCC operated between 2007 to 2015. Comparison was performed for age, sex, smoking habit, alcohol consumption, site of the tumor, the level of keratinization, T stage, lymphovascular invasion, perineural invasion, recurrence of the tumor, and survival.
Results: Of the 60 patients (18 females, 42 males), the median was 58 (range: 27 to 75) years. Seventeen patients were p16-positive, and 43 patients were p16-negative. Comparison of p16-positive and p16-negative groups according to age, sex, T-stage, tumor subsite, tumor profundity, lymphovascular invasion, perineural invasion and survival was not statistically significant (p>0.05). We found statistical difference between two groups according to tumor recurrence, smoking habit, and the degree of keratinization.
Conclusion: In patients who underwent surgical treatment after the diagnosis of zOC/OP-SCC, p16 positivity may have a predictive role in terms of tumor recurrence.

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