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Background: The aim of this study is to investigate the histopathological effects of 2-octyl-cyanoacrylate used in facial plastic operations that are applied for the fixation of cartilage graft types and the graft stabilization effect.
Methods: In the study, 16 New Zealand-type rabbits weighing between 2250 g and 2500 g, 3-4 months old, were used. Two groups were formed as the study and control groups. Those using 2-octyl-cyanoacrylate for cartilage graft fixation were defined as the study group. Those using suturing were defined as the control group. The operation was planned with cartilage grafts taken from the ears of each rabbit and the study group on the left of the sagittal suture and the control group on the right.
Results: Acute inflammation findings were found in 19 (39.6%) of the study group and 6 (14%) of the control group. Acute inflammation levels were found to be higher in the study group than in the control group (P=.006). Mild inflammation was found in 20 (41.7%) of the study group, moderate inflammation in 7 (14.6%), and severe inflammation in 2 (4.2%). Mild inflammation was detected in 10 (23.3%) of the control group. Chronic inflammation levels were higher in the study group than in the control group. Foreign body reaction was detected in 28 (58.3%) of the study group and 14 (32.6%) of the control group. Foreign body reaction levels were found to be higher in the study group than in the control group.
Conclusion: We think that the use of 2-octyl-cyanoacrylate in cartilage graft fixation is not correct as it may increase the risk of postoperative complications.
Cite this article as: Erkmen B, Mahmut A, Sürmeli M, et al. Histopathological examination of cyanoacrylate usage in cartilage graft fixation. ENT Updates. 2023;12(3): 127-132.